幸谷研究室 東海大学総合医学研究所

医学部内科学系血液腫瘍内科造血腫瘍分野

ラボの研究業績

ラボの研究業績

  1. Kotani A., Rinsho Ketsueki. 2014 Jul;55(7):780-4 "Genomic mutator Activation-induced cytidine deaminase (AID) as a therapeutic target".
  2. Kotani A., Int J Hematol. 2014 May;99(5):529-30 "Guest editorial: noncoding RNA in hematopoietic system".
  3. Okuyama K.*, Ogata J.*, Yamakawa N.*, Chanda B., Kotani A., *eaqually contributed, Int J Hematol. 2014 in press "Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis".
  4. Natsuko Yamakawa*, Kazuki Okuyama*, Jun Ogata*, Akinori Kanai, Aleksandra Helwak, Masako Takamatsu, Ken-ichi Imadome, Koh-hei Takakura, Chanda Bidisha, Natsumi Kurosaki , Haruna Yamamoto, Kiyoshi Ando, Hirotaka Matsui, Toshiya Inaba, and Ai Kotani, (* eaqually contributed)
    Nucleic Acid Research in press
    "Novel functional small RNAs are selectively loaded onto mammalian Ago1"
  5. Kazuaki Yokoyama, Nozomi Yokoyama, Kiyoko Izawa, Ai Kotani, Akira Harashima, Katsuto Hozumi, and Arinobu Tojo,
    BLOOD 122(26), 4259-63 (2013) Dec 19,
    "In vivo leukemogenic potential of an interleukin-7 receptor α chain mutant in hematopoietic stem and progenitor cells"
  6. Kazuki Okuyama, Tomokatsu Ikawa, Bernhard Gentner, Katsuto Hozumi, Ratanakanit Harnprasopwat, Jun Lu, Riu Yamashita, Daon Ha, Takae Toyoshima, Bidisha Chanda, Toyotaka Kawamata, Kazuaki Yokoyama, Shusheng Wang, Kiyoshi Ando, Harvey F. Lodish, Arinobu Tojo, Hiroshi Kawamoto, and Ai Kotani,
    "miR-126-mediated control of cell fate in B cell-myeloid progenitors as a potential alternative to transcriptional factors", Running title: miR-126 regulates B cell lineage specification, Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13410-5.
  7. Honjo T, Kobayashi M, Begum N, Kotani A, Sabouri S, Nagaoka H.
    The AID Dilemma: Infection, or Cancer?
    Adv Cancer Res. 2012;113:1-44.
  8. Toyotaka Kawamata+, Jun Lu+, Tadayuki Sato+, Masafumi Tanaka, Hitoshi Nagaoka, Yasutoshi Agata, Takae Toyoshima, Kazuaki Yokoyama, Naoki Oyaizu, Naoya Nakamura, Kiyoshi Ando, Arinobu Tojo*, and Ai Kotani*. +equally contributed *corresponding author., "Imatinib mesylate directly impairs class switch recombination through downregulation of AID. "
    Blood 2012 Mar 29;119(13):3123-7.
  9. Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M. , "Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl",
    Cancer Sci. 2011 Aug 16.
  10. Jun Lu+, Bidisha Chanda+ and Ai Kotani*+, *corresponding author +equally contributed.
    "EBV encoded miRNAs in EBV related malignancy"
    Hematology - Science and Practice 2012.

日本語総説

  1. 緒方洵、保科貴宏、山本春菜、幸谷 愛、 実験医学9月号 in press 羊土社 ”RNA-RAN相互作用の新概念”
  2. 緒方洵、保科貴宏、山本春菜、幸谷 愛、 実験医学9月号 in press 羊土社、”RNA-RAN相互作用の新概念”
  3. 奥山一生、幸谷 愛、 血液内科 vol 68 No6 p725-p729 科学評論社、”マイクロRNAによる血液細胞分化制御”
  4. 横山和明、幸谷 愛、 細胞工学 2013年1月号 学研秀潤社、”血液疾患・免疫疾患におけるエクソソーム”

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